If you are sending Twitts every minute and consider Twitter as the most important part of your day, Stop and think about it!.
Some questions for you:
1.- Do you really think that all your followers are your friends and have genuine interest on every single detail of your life?
2.- Can you stop twitting for... an hour, a day, a week?
3.- Do you find this statement offensive ? "Real friends don´t just shout randomly in to the darkness, and hope someone listen"
4.- Your answer to question two was, "oh boy, another stupid against Twitter?" If so, look at this video. If you don’t laugh, find a Psychologist.